| Date | Location | Result | |
| 2/21/22 | Oshkosh, Wis. (Kolf Sports Center) | UW-Oshkosh 65, UW-La Crosse 50 | Box score |
| 2/18/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 57, UW-Platteville 44 | Box score |
| 2/16/22 | Menomonie, Wis. (Johnson Fieldhouse) | UW-La Crosse 74, UW-Stout 60 | Box score |
| 2/12/22 | La Crosse, Wis. (Mitchell Hall) | UW-Oshkosh 59, UW-La Crosse 57 (2OT) | Box score |
| 2/9/22 | La Crosse, Wis. (Mitchell Hall) | UW-River Falls 66, UW-La Crosse 59 | Box score |
| 2/5/22 | Eau Claire, Wis. (Zorn Arena) | UW-Eau Claire 71, UW-La Crosse 58 | Box score |
| 2/2/22 | Whitewater, Wis. (Kachel Gymnasium) | UW-Whitewater 56, UW-La Crosse 54 | Box score |
| 1/26/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 64, UW-Platteville 53 | Box score |
| 1/22/22 | Stevens Point, Wis. | UW-La Crosse 67, UW-Stevens Point 49 | Box score |
| 1/19/22 | La Crosse, Wis. (Mitchell Hall) | UW-Whitewater 60, UW-La Crosse 48 | Box score |
| 1/15/22 | La Crosse, Wis. (Mitchell Hall) | UW-Eau Claire 53, UW-La Crosse 48 | Box score |
| 1/12/22 | River Falls, Wis. | UW-La Crosse 68, UW-River Falls 39 | Box score |
| 1/5/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 74, UW-Stout 61 | Box score |
| 12/30/21 | Dubuque, Iowa | UW-La Crosse 70, Loras (Iowa) 53 | Box score |
| 12/29/21 | Dubuque, Iowa | Simpson (Iowa) 85, UW-La Crosse 82 | Box score |
| 12/13/21 | Northfield, Minn. (West Gym) | UW-La Crosse 77, Carleton (Minn.) 51 | Box score |
| 12/4/21 | Oshkosh, Wis. (Kolf Sports Center) | UW-Oshkosh 55, UW-La Crosse 49 | Box score |
| 12/1/21 | Platteville, Wis. | UW-Platteville 64, UW-La Crosse 48 | Box score |
| 11/27/21 | La Crosse, Wis. (Mitchell Hall) | Simpson (Iowa) 70, UW-La Crosse 56 | Box score |
| 11/26/21 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 58, Edgewood (Wis.) 55 | Box score |
| 11/23/21 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 51, Ripon (Wis.) 39 | Box score |
| 11/20/21 | Mount Vernon, Iowa (Small Sport Center) | Cornell College (Iowa) 55, UW-La Crosse 49 | Box score |
| 11/17/21 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 73, Coe (Iowa) 44 | Box score |
| 11/13/21 | Wauwatosa, Wis. | UW-La Crosse 64, Martin Luther (Minn.) 27 | Box score |
| 11/12/21 | Wauwatosa, Wis. | UW-La Crosse 65, WashU (Mo.) 54 | Box score |
| 11/6/21 | River Forest, Ill. | UW-La Crosse 71, Concordia Chicago (Ill.) 36 | Box score |