| Date | Location | Result | |
| 3/5/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 65, UW-La Crosse 56 | Box score |
| 3/4/22 | Bloomington, Ill. (Shirk Center) | UW-La Crosse 90, Heidelberg (Ohio) 86 | Box score |
| 2/24/22 | Platteville, Wis. (Bo Ryan Court) | UW-Platteville 74, UW-La Crosse 51 | Box score |
| 2/22/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 74, UW-Stevens Point 70 | Box score |
| 2/16/22 | La Crosse, Wis. (Mitchell Hall) | UW-Stout 76, UW-La Crosse 66 | Box score |
| 2/12/22 | Oshkosh, Wis, (Kolf Sports Center) | UW-Oshkosh 80, UW-La Crosse 77 | Box score |
| 2/9/22 | River Falls, Wis. | UW-La Crosse 80, UW-River Falls 72 | Box score |
| 2/5/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 73, UW-Eau Claire 64 | Box score |
| 2/2/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 80, UW-Whitewater 68 | Box score |
| 1/29/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 95, Bethel University (Minn.) 60 | Box score |
| 1/26/22 | Platteville, Wis. (Bo Ryan Court) | UW-Platteville 76, UW-La Crosse 72 | Box score |
| 1/22/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 64, UW-Stevens Point 44 | Box score |
| 1/19/22 | Whitewater, Wis. (Williams Center) | UW-La Crosse 79, UW-Whitewater 61 | Box score |
| 1/15/22 | Eau Claire, Wis. (Zorn Arena) | UW-La Crosse 67, UW-Eau Claire 60 | Box score |
| 1/12/22 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 77, UW-River Falls 66 | Box score |
| 1/8/22 | Stevens Point, Wis. (Quandt Fieldhouse) | UW-La Crosse 73, UW-Stevens Point 59 | Box score |
| 1/5/22 | Menomonie, Wis. (Johnson Fieldhouse) | UW-La Crosse 89, UW-Stout 85 | Box score |
| 12/18/21 | Saint Bonifacius, Minn. | UW-La Crosse 67, Crown College (Minn) 43 | Box score |
| 12/11/21 | Angola, Ind. (MTI Center) | UW-La Crosse 68, Trine (Ind.) 61 | Box score |
| 12/4/21 | La Crosse, Wis. (Mitchell Hall) | UW-Oshkosh 56, UW-La Crosse 53 | Box score |
| 12/1/21 | La Crosse, Wis. (Mitchell Hall) | UW-Platteville 73, UW-La Crosse 67 | Box score |
| 11/27/21 | Waverly, Iowa | UW-La Crosse 83, Wartburg (Iowa) 78 | Box score |
| 11/23/21 | Ripon, Wis. | UW-La Crosse 75, Ripon College (Wis.) 74 (OT) | Box score |
| 11/20/21 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 83, Buena Vista (Iowa) 56 | Box score |
| 11/17/21 | Minneapolis, Minn. (Si Melby Hall) | UW-La Crosse 75, Augsburg University (Minn.) 74 (OT) | Box score |
| 11/13/21 | La Crosse, Wis. (Mitchell Hall) | UW-La Crosse 79, Marian (Wis.) 48 | Box score |
| 11/6/21 | Virginia Beach, Va. | UW-La Crosse 65, Va. Wesleyan 54 | Box score |
| 11/5/21 | Virginia Beach, Va. | UW-La Crosse 73, Methodist (N.C.) 50 | Box score |